Search on: ARISTOLOCHIC ACIDS 
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Descriptor English:   Aristolochic Acids 
Descriptor Spanish:   Ácidos Aristolóquicos 
Descriptor Portuguese:   Ácidos Aristolóquicos 
Tree Number:   D02.455.426.559.847.723.089
D02.640.139
D04.615.723.089
Definition English:   Nitro-phenanthrenes occurring in ARISTOLOCHIACEAE and other plants. They derive from stephanine (APORPHINES) by oxidative ring cleavage. The nitro group is a reactive alkylator (ALKYLATING AGENTS) that binds to biological macromolecules. Ingestion by humans is associated with nephropathy (NEPHRITIS). There is no relationship to the similar named aristolochene (SESQUITERPENES). 
History Note English:   2003 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Record Number:   37310 
Unique Identifier:   D034341 

Occurrence in VHL:
 

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